The Pigeon Forge Fire Department arrived at the museum at 8:11 p.m. after getting a 911 call reporting a traumatic incident, Chief Tony L. Watson told CNN.
Firefighters helped first responders triage the victims and prepare them for transport.
One patient was airlifted to the University of Tennessee Medical Center in Knoxville about 30 miles away, Watson said. The other two were taken by ambulance to LeConte Medical Center in Sevierville. Their conditions have not been released.
“Something caused that ice to fall off of that wall,” Watson said.
Staff had closed the museum and were clearing the area by the time firefighters arrived. “The Titanic staff did an excellent job of getting people away from the area and downstairs then evacuating them out of the building,” Watson said.
The museum reopened on Tuesday, according to a post on its Facebook page.